Lowepro Stealth Reporter AW Bags have for a long time been the only serious choice for me when traveling with camera equipment or just carrying my stuff around in town.
 
It's big enough to take a camera body with standard lens put on plus 2 additional non-L type lenses and any accessory I could need (including lens hoods). Actually its size is big enough to carry any photo equipment with a weight you'd still want to take on a journey with you in a shoulder strap type of a bag. Another matter with size also is the attention it draws on the bag. In many situations in not so safe regions a smaller bag is much better.
 

Lowepro Stealth Reporter D100 AW
Almost everything about the SR D100 AW is great. It's materials and build quality are great. The shoulder strap is really comfortable. The interior concept is ok, although I sometimes feel like there could be just a bit more space in the accessory pocket or an additional accessory pocket in the top cover. The AW (All Weather) cover saved my camera's life numerous times, be it dirt 'n dust or just rain, and last but not least this bag features SlipLocks sidewards offering the possibility to extend the bag with one or even two of Lowepro's Lens Cases.
 
The only completely useless thing on that bag is the zipper in the top cover. This thing doesn't make any sense to me. I always mind about it as a weak point in wet situations, when the AW cover would usually not yet be considered to be used, if that zipper would not be there. The basic idea of that zipper is to easily access the camera in the bag without the need to open the clip locker and main zipper. Thing is, not even the smallest body will fit through there comfortably and you need to open the bag anyway to put everything back or to access one of the additional lenses or accessories. But hey ... nothing is perfect. And this bag is otherwise the most perfect bag in this size that I ever saw.

Lowepro Inverse 100 AW Belt Packs are just a little smaller in volume. I bought that bag lately for more mountain trekking oriented trips, where you need a bag to stay in the prefered position, instead of swinging around like a bag with shoulder strap.
 
I more and more tend to minimize my equipment and ended up traveling with only my Canon EOS 5D Mark II, an EF 50mm F1.4 and an EF 16-35mm F4.0L IS, plus lens hoods and polarizers for both. The Inverse 100 is big enough to handle this set, but doesn't offer any additional space, not even a useful pocket to store the filters inside. Quite minimalistic.
 

Lowepro Stealth Reporter D100 AW

B&W International outdoor.cases are the second thing I can just recommend out of experience for rough off-road or outdoor action like canoeing or safari. They are available in several sizes. All of them are 100% dust and water proof (up to 5m) as well as resistant against chemicals. They are built of ABS plastic and are highly resistant against temperature (save from -40°C up to 80°C) and damage by being dropped (usually withstand drop tests up to 3m). The interior can be completely cushioned with foam to absorb any shocks that might damage camera bodies or lenses, alternatively there are also freely configurable padded partition inserts available. Thus these cases are the ideal armor for your camera equipment while on tour by boat, motorbike or car, and are also the ideal storage place at home, as long as you are not up for vitrines.
 
The bigger versions feature a very unique locking system for easy access (Type 30 and upwards). Shoulder strap and backpack carrier are optionally available.
 

B&W Type 20 and Type 30 outdoor.cases
For comparison: Pelican cases are made of Polypropylene. They are given 10m diving ability, temperature resistance from -25°C up to 80°C, withstand drop tests up to 1.2m and stacking loads of up to 180kg. B&W outdoor.cases as well as Peli cases are covered by a lifetime warranty. Peli cases, however, do not feature that smart kind of opening mechanism ;).
 
The following B&W outdoor.cases are available:
 

Model		Type	Int. Size (mm)	Ext. Size (mm)	Weight (g)	Volume (l)	Color¹
	Type 05	Box	205 x 145 x 70	225 x 170 x 85	500	2	B + O + Gt
	Type 10	Suitcase	250 x 180 x 80	275 x 220 x 95	600	4	B + O
	Type 20	Suitcase	250 x 180 x 140	275 x 225 x 155	1200	6	B + O
	Type 30	Suitcase	335 x 210 x 135	365 x 265 x 155	1700	9	B + O
	Type 40	Suitcase	385 x 265 x 150	410 x 325 x 165	1900	15	B + O
	Type 50	Suitcase	420 x 300 x 170	455 x 365 x 185	3000	21	B + O
	Type 55	Suitcase	420 x 300 x 300	455 x 365 x 315	4600	38	B
	Type 61	Suitcase	480 x 360 x 210	500 x 425 x 320	4600	36	B + O
	Type 65	Suitcase	590 x 420 x 195	665 x 495 x 210	7500	48	B
	Type 66	Trolley	535 x 360 x 195	590 x 430 x 230	6700	38	B
	Type 67	Trolley	535 x 360 x 245	590 x 430 x 285	7300	47	B
	Type 68	Trolley	590 x 425 x 295	665 x 500 x 335	10500	74	B
	Type 70	Trolley	675 x 425 x 210	755 x 500 x 250	9000	60	B
	Type 72	Trolley	1150 x 355 x 155	1210 x 430 x 175	8500	63	B
	Type 78	Trolley	755 x 535 x 370	840 x 615 x 410	15200	150	B
	Type 80	Bag	255 x 200 x 195	270 x 235 x 205	2000	10	G
	Type 85	Bag	310 x 235 x 230	340 x 275 x 245	3500	17	G
	Type 90	Bag	375 x 255 x 265	410 x 295 x 280	4000	25	G

Model		Compatible with	Weight (g)	Volume (l)	Color¹
	BPS 40	Backpack System for Type 40 Cases	1500		B
	BPS 50	Backpack System for Type 50 Cases	1500		B
	BPS 61	Backpack System for Type 61 Cases	1500		B
	CS	Shoulder Strap for Suitcases			B

¹Colors: B = black, O = orange, G = gray, Gt = transparent green